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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10279/124

Autori: Romanò, Carlo L.; A.O. Istituto Ortopedico Gaetano Pini - Milano.
Meani, Enzo; A.O. Istituto Ortopedico Gaetano Pini - Milano.
Original title: Fattori di crescita autologhi nella chirurgia ossea ricostruttiva dopo infezione
Titolo: Autologous growth factors in bone reconstruction after infection
Abstract: Le infezioni ossee richiedono frequentemente un trattamento ricostruttivo delle perdite di sostanza ossea dovute al processo settico di per sé e alle procedure chirurgiche necessarie per rimuovere i tessuti infetti. Molto scarsa è tuttavia la letteratura per ciò che riguarda la possibilità di usare, anche in questi casi, un apporto biologico mediante innesti ossei, autologhi od omologhi, in associazione a innesto locale di fattori di crescita autologhi (AGF) che abbiano attività osteoinduttiva
English abstract: Bone infection often requires surgical reconstruction of bone defect either due to the septic process and/or the surgical debridment. In this original paper the results of the use of autologous growth factors and bone grafts for the treatment of bone defects resulting from bone infection are briefly reported. Materials & methods: From May 2002 to December 2003, 14 patients, affected by bone defects resulting from bone infections, were surgically treated with Platelet-Rich Plasma (PRP) and morcellized autologous (5 patients) or homologous (9 patiens) bone grafts. There were 3 non-unions (1 ulna, 1 humerus, 1 femur), 1 incomplete union of the femur, 9 femoral and 1 acetabular peri-prosthetic bone loss. All the patients did not show signs or symptoms of active infection at the time of treatment. Results: Bone grafts osteointegration has been achieved in all but one case (non-union of the ulna). No infection recurrence and no general or local adverse events connected to the grafts and PRP use were noted. Conclusions: This is the first report on the safety of the use of autologous growth factors and bone grafts for the treatment of bone defects resulting from bone infections. This technique appears useful for the treatment of non-unions and peri-prosthetic bone loss, once infection has been adequately resolved with previous accurate surgical debridment and antibiotic therapy
English Mesh: Bone Diseases, Infectious
Fibroblast Growth Factors
Reconstructive Surgical Procedures
Data: 2007
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